Which of the following medications is typically not refrigerated?

The EpiPen, which contains epinephrine, is typically not required to be refrigerated. It can be stored at room temperature, although it should be protected from light and extreme temperatures. Storing it properly ensures that the medication remains effective when needed in emergencies, such as treating severe allergic reactions.

Insulin is often recommended to be stored in the refrigerator, especially until it is opened, but can be kept at room temperature for a limited time once in use. Similarly, pneumococcal vaccines require refrigeration to maintain their efficacy. Live attenuated vaccines also need to be refrigerated to preserve their effectiveness, as they are sensitive to temperature changes. Thus, the EpiPen’s ability to be stored at room temperature makes it the exception among the listed medications.